Record: 5-7 Overall / 1-7 Conference
| EVENT | DATE | VENUE/CITY | |
| Michigan Wolverines vs. Western Michigan Broncos |
9/05/2009 | Michigan Stadium Ann Arbor, MI |
31 – 7 W |
| Michigan Wolverines vs. Notre Dame Fighting Irish |
9/12/2009 | Michigan Stadium Ann Arbor, MI |
38 – 34 W |
| Michigan Wolverines vs. Eastern Michigan Eagles |
9/19/2009 | Michigan Stadium Ann Arbor, MI |
45 – 17 W |
| Michigan Wolverines vs. Indiana Hoosiers |
9/26/2009 | Michigan Stadium Ann Arbor, MI |
36 – 33 W |
| Michigan State Spartans vs. Michigan Wolverines |
10/03/2009 | Spartan Stadium East Lansing, MI |
26 – 20 OT L |
| Iowa Hawkeyes vs. Michigan Wolverines |
10/10/2009 | Kinnick Stadium Iowa City, Iowa |
30 – 28 L |
| Michigan Wolverines vs. Delaware State Hornets |
10/17/2009 | Michigan Stadium Ann Arbor, MI |
63 – 6 W |
| Penn State Nittany Lions vs. Michigan Wolverines |
10/24/2009 | Michigan Stadium Ann Arbor, MI |
35 – 10 L |
| Illinois Fighting Illini vs. Michigan Wolverines |
10/31/2009 | Memorial Stadium Champaign, IL |
38 – 13 L |
| Michigan Wolverines vs. Purdue Boilermakers |
11/07/2009 | Michigan Stadium Ann Arbor, MI |
38 – 36 L |
| Wisconsin Badgers vs. Michigan Wolverines |
11/14/2009 | Camp Randall Stadium Madison, WI |
45 – 24 L |
| Michigan Wolverines vs. Ohio State Buckeyes |
11/21/2009 | Michigan Stadium Ann Arbor, MI |
21 – 10 L |
