| EVENT | DATE | VENUE/CITY | |
| Michigan Wolverines vs. Connecticut Huskies |
9/04/2010 | Michigan Stadium Ann Arbor, MI |
- |
| Michigan Wolverines vs. Notre Dame Fighting Irish |
9/11/2010 | Michigan Stadium South Bend, IN |
- |
| Michigan Wolverines vs. Massachusetts Minutemens |
9/18/2010 | Michigan Stadium Ann Arbor, MI |
- |
| Michigan Wolverines vs. Bowling Green Falcons |
9/25/2010 | Michigan Stadium Ann Arbor, MI |
- |
| Indiana Hoosiers vs. Michigan Wolverines |
10/02/2010 | Memorial Stadium Bloomington, IN |
- |
| Michigan State Spartans vs. Michigan Wolverines |
10/09/2010 | Michigan Stadium East Lansing, MI |
- |
| Michigan Wolverines vs. Iowa Hawkeyes |
10/16/2010 | Michigan Stadium Ann Arbor, MI |
- |
| Penn State Nittany Lions vs. Michigan Wolverines |
10/30/2010 | Beaver Stadium University Park, PA |
- |
| Illinois Fighting Illini vs. Michigan Wolverines |
11/06/2010 | Michigan Stadium Ann Arbor, MI |
- |
| Purdue Boilermakers vs. Michigan Wolverines |
11/13/2010 | Ross-Ade Stadium West Lafayette, IN |
- |
| Wisconsin Badgers vs. Michigan Wolverines |
11/20/2010 | Camp Randall Stadium Madison, WI |
- |
| Ohio State Buckeyes vs. Michigan Wolverines |
11/27/2010 | Ohio Stadium Columbus, OH |
- |
2010 Michigan Wolverines Football Schedule
On October 21, 2010
